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Synergism between porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis in swine

Identifieur interne : 001917 ( Main/Exploration ); précédent : 001916; suivant : 001918

Synergism between porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis in swine

Auteurs : Robert W. Wills [États-Unis] ; Jeffery T. Gray [États-Unis] ; Paula J. Fedorka-Cray [États-Unis] ; K.-J. Yoon [États-Unis] ; Scott Ladely [États-Unis] ; J. J. Zimmerman [États-Unis]

Source :

Veterinary Microbiology [ 0378-1135 ] ; 2000.

RBID : ISTEX:74743F71128703B01C6A984DCBD9410F0A1A0D71

English descriptors

Abstract

Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis are two leading causes of economic loss in the swine industry. While respiratory disease is common in both S. choleraesuis and PRRSV infections, the factors that contribute to its development remain largely undefined. We investigated the interaction of PRRSV, S. choleraesuis, and stress in 5-week-old swine. All combinations of three factors (inoculation with S. choleraesuis on Day 0, PRRSV on Day 3, and treatment with dexamethasone on Days 3–7) were used to produce eight treatment groups in two independent trials. Fecal samples, tonsil and nasal swabs, serum samples and postmortem tissues were collected for bacteriologic and virologic examinations. No clinical signs were observed in pigs inoculated with only PRRSV or only S. choleraesuis. In contrast, pigs which were dually infected with S. choleraesuis and PRRSV exhibited unthriftiness, rough hair coats, dyspnea, and diarrhea. The pigs which received all three treatment factors were the most severely affected and 43% (three of seven) of the animals in this group died. Individuals in this group shed significantly higher quantities of S. choleraesuis in feces and had significantly higher serum PRRSV titers compared to other treatments (p≤0.05). In addition, S. choleraesuis and PRRSV were shed longer and by more pigs in this group than other groups and S. choleraesuis was recovered from more tissues in this group on Day 21 post inoculation. These results suggested that PRRSV, S. choleraesuis, and dexamethasone acted synergistically to produce a syndrome similar to that observed in the field.

Url:

https://api.istex.fr/ark:/67375/6H6-X8FJ5774-B/fulltext.pdf

DOI: 10.1016/S0378-1135(99)00175-3

Affiliations:

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Interaction</term>
<term>Pig-bacteria</term>
<term>Pig-viruses</term>
<term>Porcine reproductive and respiratory syndrome (PRRS)</term>
<term>Salmonella choleraesuis</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Alveolar macrophages</term>
<term>Bactericidal activity</term>
<term>Biomedical sciences</term>
<term>Body weight</term>
<term>Carrier state</term>
<term>Cecal contents</term>
<term>Ceftiofur sodium</term>
<term>Cell monolayers</term>
<term>Choleraesuis</term>
<term>Choleraesuis infection</term>
<term>Clinical disease</term>
<term>Clinical outbreaks</term>
<term>Clinical signs</term>
<term>Concurrent infection</term>
<term>Culture medium</term>
<term>Dexamethasone</term>
<term>Dexamethasone treatment</term>
<term>Elsevier science</term>
<term>Experimental conditions</term>
<term>Experimental reproduction</term>
<term>Fecal</term>
<term>Fecal sample</term>
<term>Fecal samples</term>
<term>Feces</term>
<term>Fever response</term>
<term>Full model</term>
<term>Gnotobiotic pigs</term>
<term>Greater proportion</term>
<term>Important role</term>
<term>Infection</term>
<term>Inoculated</term>
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<term>Likelihood ratio</term>
<term>Lung lavage</term>
<term>Macrophage</term>
<term>Microbiology</term>
<term>Middle ileum</term>
<term>Multiple range test</term>
<term>Mystery swine disease</term>
<term>Nasal swabs</term>
<term>Nursery pigs</term>
<term>Other groups</term>
<term>Pairwise comparisons</term>
<term>Pig</term>
<term>Pigs inoculated</term>
<term>Porcine</term>
<term>Porcine alveolar macrophages</term>
<term>Porcine epidemic abortion</term>
<term>Positive tissues</term>
<term>Postmortem tissues</term>
<term>Poultry microbiology research unit</term>
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<term>Prrs</term>
<term>Prrsv</term>
<term>Prrsv infection</term>
<term>Prrsv infections</term>
<term>Pulmonary intravascular macrophages</term>
<term>Quantitative recovery</term>
<term>Rectal swabs</term>
<term>Regression plots</term>
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<term>Respiratory syndrome</term>
<term>Respiratory syndrome virus</term>
<term>Rough hair coats</term>
<term>Russell research center</term>
<term>Salmonella</term>
<term>Salmonella choleraesuis</term>
<term>Salmonella choleraesuis infection</term>
<term>Salmonella typhimurium</term>
<term>Same superscript</term>
<term>Sample collection</term>
<term>Secondary infections</term>
<term>Serum samples</term>
<term>Standard deviation</term>
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<term>Tonsil</term>
<term>Treatment differences</term>
<term>Treatment group</term>
<term>Treatment groups</term>
<term>Veterinary</term>
<term>Veterinary microbiology</term>
<term>Virus titers</term>
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<front><div type="abstract" xml:lang="en">Abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis are two leading causes of economic loss in the swine industry. While respiratory disease is common in both S. choleraesuis and PRRSV infections, the factors that contribute to its development remain largely undefined. We investigated the interaction of PRRSV, S. choleraesuis, and stress in 5-week-old swine. All combinations of three factors (inoculation with S. choleraesuis on Day 0, PRRSV on Day 3, and treatment with dexamethasone on Days 3–7) were used to produce eight treatment groups in two independent trials. Fecal samples, tonsil and nasal swabs, serum samples and postmortem tissues were collected for bacteriologic and virologic examinations. No clinical signs were observed in pigs inoculated with only PRRSV or only S. choleraesuis. In contrast, pigs which were dually infected with S. choleraesuis and PRRSV exhibited unthriftiness, rough hair coats, dyspnea, and diarrhea. The pigs which received all three treatment factors were the most severely affected and 43% (three of seven) of the animals in this group died. Individuals in this group shed significantly higher quantities of S. choleraesuis in feces and had significantly higher serum PRRSV titers compared to other treatments (p≤0.05). In addition, S. choleraesuis and PRRSV were shed longer and by more pigs in this group than other groups and S. choleraesuis was recovered from more tissues in this group on Day 21 post inoculation. These results suggested that PRRSV, S. choleraesuis, and dexamethasone acted synergistically to produce a syndrome similar to that observed in the field.</div>
</front>
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Synergism between porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis in swine

Synergism between porcine reproductive and respiratory syndrome virus (PRRSV) and Salmonella choleraesuis in swine

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri